MOLECULE

(1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylidene-5-oxatricyclo[8.2.0.04,6]dodecane

Caryophyllene oxide belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units. Caryophyllene oxide is an extremely weak basic (essentially neutral) compound (based on its pKa). Caryophyllene oxide is a naturally occurring sesquiterpenederived from Cryophyllene. Caryophyllene oxide is one of the many sesquiterpenes found in cannabis plants and their essential oils (PMID: 6991645). Caryophyllene oxide is one of the major compounds found in the essential oil of Salvia spinosa (63.0%). Salvia spinosa essential oil exhibites antimicrobial, cytotoxicity, antioxidant and enzyme inhibitory activities (https://doi.org/10.1016/j.jff.2015.09.011). Caryophyllene oxide is a volatile compound found in different species of citrus fruits (https://doi.org/10.1016/j.foodchem.2017.03.040).