MOLECULE

Chalconaringenin

Chalconaringenin, also known as isosalipurpol or naringenin chalcone, belongs to the class of organic compounds known as 2'-hydroxychalcones. These are organic compounds containing chalcone skeleton that carries a hydroxyl group at the 2'-position. Thus, chalconaringenin is considered to be a flavonoid lipid molecule. Naringenin chalcone can spontaneously cyclize to naringenin (a flavanone). Chalconaringenin is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, Chalconaringenin has been detected, but not quantified in, several different foods, such as canola, grapefruit/pummelo hybrids, yellow wax beans, horseradish tree, and wild carrots. This could make chalconaringenin a potential biomarker for the consumption of these foods. In plant cells, this process is catalyzed by chalcone isomerase. It is synthesized from 4-coumaroyl-CoA and malonyl-CoA by chalcone synthase (CHS), a key enzyme in the phenylpropanoid pathway. Naringenin chalcone is a common chalconoid (or chalcone, not to be confused with the compound chalcone). Chalconaringenin is expected to be in Cannabis as all living plants are known to produce and metabolize it.