MOLECULE

5-Aminoimidazole ribonucleotide

5-Aminoimidazole ribonucleotide, also known as 5'-phosphoribosyl-5-aminoimidazole or AIR, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. 5-Aminoimidazole ribonucleotide is a very strong basic compound (based on its pKa). 5-Aminoimidazole ribonucleotide exists in all living species, ranging from bacteria to humans. Within humans, 5-aminoimidazole ribonucleotide participates in a number of enzymatic reactions. In particular, 5-aminoimidazole ribonucleotide can be biosynthesized from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate; which is mediated by the enzyme multifunctional protein ADE2. In addition, 5-aminoimidazole ribonucleotide can be biosynthesized from phosphoribosylformylglycineamidine through its interaction with the enzyme trifunctional purine biosynthetic protein adenosine-3. A 1-(phosphoribosyl)imidazole that is 5-aminoimidazole in which the proton at position 1 has been replaced by a 5-phospho-beta-D-ribofuranosyl group. In humans, 5-aminoimidazole ribonucleotide is involved in the metabolic disorder called the gout or kelley-seegmiller syndrome pathway. Outside of the human body, 5-Aminoimidazole ribonucleotide has been detected, but not quantified in, several different foods, such as cascade huckleberries, anises, red bell peppers, spirulina, and black mulberries. This could make 5-aminoimidazole ribonucleotide a potential biomarker for the consumption of these foods. 5-Aminoimidazole ribonucleotide is expected to be in Cannabis as all living plants are known to produce and metabolize it.