MOLECULE

6-Phosphonoglucono-D-lactone

6-Phosphonoglucono-D-lactone, also known as D-glucono-1,5-lactone 6-phosphate or 6-PGDL, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. An aldonolactone phosphate comprising D-glucono-1,5-lactone having the phosphate group at the 6-position. 6-Phosphonoglucono-D-lactone is an extremely weak basic (essentially neutral) compound (based on its pKa). 6-Phosphonoglucono-D-lactone exists in all living species, ranging from bacteria to humans. Within humans, 6-phosphonoglucono-D-lactone participates in a number of enzymatic reactions. In particular, 6-phosphonoglucono-D-lactone can be converted into 6-phosphogluconic acid; which is mediated by the enzyme 6-phosphogluconolactonase. In addition, 6-phosphonoglucono-D-lactone can be biosynthesized from β-D-glucose 6-phosphate; which is mediated by the enzyme glucose-6-phosphate 1-dehydrogenase. In humans, 6-phosphonoglucono-D-lactone is involved in the metabolic disorder called the warburg effect pathway. Outside of the human body, 6-Phosphonoglucono-D-lactone has been detected, but not quantified in, several different foods, such as beans, soft-necked garlics, peppermints, sparkleberries, and brazil nuts. This could make 6-phosphonoglucono-D-lactone a potential biomarker for the consumption of these foods. 6-Phosphonoglucono-D-lactone is expected to be in Cannabis as all living plants are known to produce and metabolize it.