MOLECULE

7,8-Dihydroneopterin

7,8-Dihydroneopterin, also known as NPR, belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland. 7,8-Dihydroneopterin is a strong basic compound (based on its pKa). 7,8-Dihydroneopterin exists in all living organisms, ranging from bacteria to humans. Within humans, 7,8-dihydroneopterin participates in a number of enzymatic reactions. In particular, 7,8-dihydroneopterin can be biosynthesized from sepiapterin through its interaction with the enzyme sepiapterin reductase. In addition, 7,8-dihydroneopterin can be biosynthesized from sepiapterin through the action of the enzyme carbonyl reductase [nadph] 1. In humans, 7,8-dihydroneopterin is involved in the metabolic disorder called hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps). Outside of the human body, 7,8-Dihydroneopterin has been detected, but not quantified in, several different foods, such as garden tomato (var.), black huckleberries, common beans, pak choy, and tree ferns. This could make 7,8-dihydroneopterin a potential biomarker for the consumption of these foods. 7,8-Dihydroneopterin is expected to be in Cannabis as all living plants are known to produce and metabolize it.