MOLECULE

A disintegrin and metalloproteinase with thrombospondin motifs 1

Involved in metalloendopeptidase activity Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture