MOLECULE

Borneol

Borneol is a bornane monoterpenoid that is 1,7,7-trimethylbicyclo[2.2.1]heptane substituted by a hydroxy group at position 2. It has a role as a metabolite and a volatile oil component.

Summary from ChEBI, via PubChem.

Identity

Chemistry

Formula: C10H18O
Molecular weight: 154.25 g/mol
IUPAC name: 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
InChIKey: DTGKSKDOIYIVQL-UHFFFAOYSA-N
SMILES: CC1(C2CCC1(C(C2)O)C)C
PubChem: CID 64685 ↗

Provenance

Contributing sources

PubChem
ChEBI

Human evidence in progress

Registered clinical trials

Edaravone Dexborneol for Post-Stroke Epilepsy not yet recruiting

Post-stroke Epilepsy, Post-stroke Seizure · Phase 3 · 160 participants · NCT07604350
Phase III Clinical Trial of Y-2 Sublingual Tablets in the Treatment of Acute Ischemic Stroke completed

Stroke · Phase 3 · 914 participants · NCT04950920
Nasal Irrigation With Chinese Herbal Medicine as an Adjunctive Treatment in Allergic Rhinitis completed

Rhinitis, Allergic, Nasal Lavage, Medicine, Chinese Traditional · Phase 2 · 38 participants · NCT05901532
Acupoint Application in Patients With Stable Angina Pectoris (AASAP) completed

Stable Angina Pectoris · EARLY_Phase 1 · 200 participants · NCT02029118
Safety, Tolerability and Pharmacokinetics of Y-2(Edaravone And Borneol) Sublingual Tablet unknown

Stroke, Acute, Intracranial Hemorrhages · Phase 1 · 24 participants · NCT03495206

5 registered on ClinicalTrials.gov naming this molecule as an intervention. See all terpene trials.

Evidence

Literature

All-Natural Injectable Antibacterial Hydrogel Enabled by Chitosan and Borneol

Biomacromolecules · Published 2024 · PMID 38145887
Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol

Biomed Pharmacother · Published 2023 · PMID 37321057
Discovery of 2-Ethynylisoborneol as a Highly Potent Anti-seizure Agent

J Med Chem · Published 2025 · PMID 40548561
Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke: A Phase III, Randomized, Double-Blind, Comparative Trial

Stroke · Published 2021 · PMID 33588596
[Research progress of natural borneol resources]

Zhongguo Zhong Yao Za Zhi · Published 2021 · PMID 33645052
Traditional Chinese Medicine Borneol-Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis-Adaptive Treatment of Ischemic Stroke

Adv Sci (Weinh) · Published 2025 · PMID 39804950