MOLECULE

Cannabichromevarinic acid

Cannabichromevarinic acid (CBCVA), a biosynthetic derivative of cannabigerovarinic acid (CBGVA),  is a non-psychoactive component of cannabis. CBCVA is a C3 analogue of cannabichromenic acid. CBCVA is one of the more than 100 cannabinoids found in Cannabis sativa plants. As its precursor, cannabigerovarinic acid, CBCVA is a phytocannabinoid that belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. Cannabichromenic acid is characterized by the presence of a chromene (1-benzopyran) moiety in the center of the structure. This chromene arrangement results from the cyclization of the isoprenoid sidechain onto the hydroxyl group in position four of cannabigerovarinic acid, yielding a pyrane type ring. Cannabichromevarinic acid is a molecule of mixed biosynthetic oDOI: rigin, in which its aromatic moiety (derived from divarinic acid) occurs through the polyketide biosynthetic pathway while the prenylated sidechain derives from the MEP pathway of the terpenoids (DOI: 10.1016/B978-0-12-800756-3.00002-8). As such, cannabichromevarinic acid can be considered a polyketide, a monoterpenoid and a resorcinol, due to the meta arrangement of its two hydroxyl groups on the benzene ring.  CBCVA was one of four propyl cannabinoid acids isolated from Thai Cannabis, 'Meao Variant' in 1977 (DOI: 10.1248/cpb.25.2306).