MOLECULE

Cannabielsoic acid B

Cannabielsoic acid B, also known as cannabielsoate B or CBEA-C5 B, is a phytocannabinoid that belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. Cannabielsoic acid B is a dihydroxybenzoic acid derived from cannabidiolic acid. As such, it is a molecule of mixed biosynthetic origin, in which its aromatic moiety (derived from olivetolic acid) occurs through the polyketide biosynthetic pathway while the prenylated sidechain derives from the MEP pathway of the terpenoids (DOI: 10.1016/B978-0-12-800756-3.00002-8). Thus, cannabielsoic acid B can be considered a polyketide, a monoterpenoid and a resorcinol derivative, due to the meta arrangement of its two hydroxil groups on the bencene ring. Cannabielsoic acid B, also belongs to the class of cannabis compounds known as Cannabielsoins. There are two types of cannabielsoic acids, cannabielsoic acid A (CBEA-C5 A) and cannabielsoic acid B (CBEA-C5 B). The inclusion of cannabielsoic acids as Cannabis natural products is somewhat controversial because they have been isolated and identified infrequently and also because they can be obtained by the photo-oxidation of CBD (cannabidiol). However, cannabielsoic acids have been repeatedly mentioned in the literature as natural cannabinoids and are considered as a part of the 120 cannabinoid compounds found in cannabis plants (PMID: 6991645).