MOLECULE

Cannabiorcol

Cannabiorcol (CBN-C1), also known as Cannabinol-C1, belongs to the class of organic compounds known as dibenzopyrans. These are organic heterocyclic compounds with a structure containing a dibenzopyran moiety, made up of two benzene rings fused to a central pyran ring. Cannabinol-C1 also belongs to the class of cannabis compounds known as cannabinols or CBNs. The best known and most abundant CBN is cannabinol or cannabinol-C5 (CBN or CBN-C5). CBN has a 5-carbon aliphatic chain attached to its phenol group, while CBN-C1 has a methyl group attached at position 6 of its phenol group. Other CBNs have 2, 3 or 4 carbon atom sidechains. These shorter chain cannabinols are even less abundant than CBN-C5. Cannabinols are mildly psychoactive cannabinoids found only in trace amounts (PMID: 1221432) and are mostly found in aged cannabis (PMID:26870049). Pharmacologically relevant quantities of CBN-C5 are formed as a metabolite of tetrahydrocannabinol, which is also known as THC (PMID: 1140243). Cannabinols act as partial agonists of the CB1 receptors but tend to have higher affinities to CB2 receptors. The relative activity and CB1/CB2 affinity of CBN-C1 versus CBN-C5 has not been determined. Cannabiorcol is one of more than 120 cannabinoid compounds that can be found in cannabis plants (PMID: 6991645).