MOLECULE

Cannabispirenone-B

Cannabispirenone belongs to the class of organic compounds known as indanes. Indanes are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring. It is formally classified as a phenol. Cannabispirenone is a naturally occuring organic compound and one of the spiro-indane compounds found in cannabis plants. Spiro compounds are cyclic compounds that include two rings which share a single atom (usually a carbon). The simplest example of this type of compound is Spiro[2.2]pentane. Cannabispirenone is a neutral, hydropobic molecule that is insoluble in water. There are two known Cannabispirenone isomers including Cannabispirenone A and B. Cannabispirenone A and B are non-cannabinoid phenols that have been identified in Cannabis sativa (DOI: 10.1039/P19820001477). Cannabispirenone A was first identified from the dried leaves of a South African variant grown in France in 1976 (DOI: 10.1016/0040-4020(76)80149-4). A year later it was isolated from the South African variant grown in Mississippi and was named as dehydrocannabispiran (DOI: 10.1016/0040-4020(77)80249-4). It was also identified in the Japanese Kumamoto strain (DOI:10.1248/cpb.26.3641). Its structure resembles a synthetic compound which was found to potentiate the estrogenic activity of Stilbestrol (DOI: 10.1016/0040-4020(77)80249-4, PMID: 1255671).