MOLECULE

Dihydroxyacetone phosphate

Dihydroxyacetone phosphate, also known as dihydroxy-acetone-p or 3-hydroxy-2-oxopropyl phosphate, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. Dihydroxyacetone phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Click on genes, proteins and metabolites below to link to respective articles. It is rapidly and reversibly isomerised to glyceraldehyde 3-phosphate. Dihydroxyacetone phosphate exists in all living species, ranging from bacteria to humans. Within humans, dihydroxyacetone phosphate participates in a number of enzymatic reactions. In particular, ubiquinol-8 and dihydroxyacetone phosphate can be biosynthesized from coenzyme Q10 and glycerol 3-phosphate through the action of the enzyme glycerol-3-phosphate dehydrogenase, mitochondrial. In addition, dihydroxyacetone phosphate can be converted into glycerol 3-phosphate; which is catalyzed by the enzyme glycerol-3-phosphate dehydrogenase [nad(+)], cytoplasmic. Enzyme 5.3.1.1 at KEGG Pathway Database. In humans, dihydroxyacetone phosphate is involved in the metabolic disorder called the mitochondrial electron transport chain pathway. Outside of the human body, Dihydroxyacetone phosphate has been detected, but not quantified in, several different foods, such as cardamoms, dates, red beetroots, oil-seed camellia, and kai-lans. This could make dihydroxyacetone phosphate a potential biomarker for the consumption of these foods. Dihydroxyacetone phosphate is a potentially toxic compound. DHAP is a precursor to 2-oxopropanal. Dihydroxyacetone phosphate, with regard to humans, has been found to be associated with several diseases such as lewy body disease, frontotemporal dementia, and alzheimer's disease; dihydroxyacetone phosphate has also been linked to the inborn metabolic disorder transaldolase deficiency. In the Calvin cycle, DHAP is one of the products of the sixfold reduction of 1,3-bisphosphoglycerate by NADPH. Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is the anion with the formula HOCH2C(O)CH2OPO32-. Dihydroxyacetone phosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.