MOLECULE

Guanosine diphosphate mannose

Guanosine diphosphate mannose, also known as gdpmannose or GDP-alpha-D-mannose, belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Guanosine diphosphate mannose is a strong basic compound (based on its pKa). Guanosine diphosphate mannose exists in all living species, ranging from bacteria to humans. Within humans, guanosine diphosphate mannose participates in a number of enzymatic reactions. In particular, guanosine diphosphate mannose can be biosynthesized from D-mannose 1-phosphate through its interaction with the enzyme mannose-1-phosphate guanyltransferase beta. In addition, guanosine diphosphate mannose can be converted into GDP-4-dehydro-6-deoxy-D-mannose; which is catalyzed by the enzyme GDP-mannose 4,6 dehydratase. In humans, guanosine diphosphate mannose is involved in the metabolic disorder called fructosuria. Outside of the human body, Guanosine diphosphate mannose has been detected, but not quantified in, several different foods, such as other bread, feijoa, chanterelles, cherimoya, and romaine lettuces. This could make guanosine diphosphate mannose a potential biomarker for the consumption of these foods. The alpha-anomer of GDP-D-mannose. Guanosine diphosphate mannose is expected to be in Cannabis as all living plants are known to produce and metabolize it.