MOLECULE

(-)-Globulol

(-)-Globulol or Globulol belongs to the class of organic compounds known as 5,10-cycloaromadendrane sesquiterpenoids. These are aromadendrane sesquiterpenoids that arise from the C5-C10 cyclization of the aromadendrane skeleton. Sesquiterpenoids are terpenes that contain 15 carbon atoms and are comprised of three isoprene units. The biosynthesis of sesquiterpenes is known to occur mainly through the mevalonic acid pathway (MVA), in the cytosol. However, recent studies have found evidence of pathway crosstalk with the methyl-eritritol-phosphate (MEP) pathway in the plastid (PMID: 19932496, 17710406).. Farnesyl diphosphate (FPP) is a key intermediate in the biosynthesis of cyclic sesquiterpenes. FPP undergoes several cyclization reactions to yield a diverse number of cyclic arrangements. Globulol has been identified in the essential oil from Eugenia uniflora L. (pitanga) (1.5-7.4% relative to total oil constituents) (PMID: 32092893), the essential oil of the fruits of Eucalyptus globulus (southern blue gum) (10.69% relative to total oil constituents) (PMID: 20727725), the essential oil from Hyptis mutabilis (tropical bushmint) (11.6%-26.6% relative to total oil constituents) (PMID: 24068193), the essential oil of the leaves of Lophostemon species (a genus of 4 species of evergreen tree in the myrtle family Myrtaceae native to Australia) (4.7%-15.9% relative to total oil constituents) (DOI: 10.1002/(SICI)1099-1026(200001/02)15:1<17::AID-FFJ859>3.0.CO;2-D), and also in cannabis inflorescence (0.06-0.1% relative to total terpenoids) (PMID: 32094454). It has been shown to have sedative, anesthetic activities (PMID: 24068193; DOI: 10.1111/raq.12245) and antimicrobial effects (PMID: 18569693).