MOLECULE

(-)-Limonene

d-Limonene, also known as dipentene, belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes. Thus, D-limonene is considered to be an isoprenoid lipid molecule. d-Limonene is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. (-)-Limonene is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Identity

Chemistry

Indexed entity. No structure record on file yet.

Provenance

Contributing sources

cannabisdb

Human evidence in progress

Registered clinical trials

Behavioral Pharmacology of Orally Administered THC and D-limonene recruiting

Subjective Drug Effects, THC, D-limonene · Phase 1 · 65 participants · NCT06378957
CYP2C19 Variants and Limonene Metabolism recruiting

CYP2C19 Genetic Variants · 20 participants · NCT05078723
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC recruiting

Xerostomia · Phase 1 · 40 participants · NCT04392622
New Non-invasive Biomarkers of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) completed

Healthy, Simple Steatosis (SS), Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) · 172 participants · NCT06647095
Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution completed

Fatty Liver · EARLY_Phase 1 · 57 participants · NCT04853082
Limonene Study in Women With Breast Cancer completed

Breast Cancer · Phase 1 · 59 participants · NCT01046929
Human Breast Tissue Bioavailability of Topically Applied Limonene completed

Breast Cancer · Phase 1 · 103 participants · NCT01459172
Limonene for Pulmonary Nodule Chemoprevention unknown

Pulmonary Nodules · Phase 2 · 160 participants · NCT05525260

8 registered on ClinicalTrials.gov naming this molecule as an intervention. See all terpene trials.